Announcements

Published Online: January 02 2007 | ss20070101a1
Keywords: CELL BIOLOGY | PSYCHOLOGY | US | FDA | clone animal | foods derived from clones' offspring | WMD

CLONE: Who wants to back sale of source-anonymous meat?

Lin PU
CELL BIOLOGY; PSYCHOLOGY: The U. S. FDA sent a new year's gift to the industries that producing the human foods derived from clones' offspring. The agency believes the safety of animal clones, and therefore strongly intends to issue passport for these foods without source labels. :: Lively updated news: V20070102...0123

 

Lively updated news: V20070102...0123

 

Smooth-spoken

On 28 December 2006, the U. S. Food and Drug Administration issued a new year's gift to the industries that producing the human foods (milk and meat) derived from clones' offspring. The attached assessment claimed that cloned cattle, pigs and goats produced food "as safe as the food we eat every day", because the cloned animals produced food products virtually indistinguishable from more traditional offerings [1].

With a lengthy assessment report, which concluded that "there is no science based reason to recommend any additional safeguards" [2], the agency "believes that food products from clone progeny are suitable to enter the food and feed supply" and "therefore", "we do not have any recommendations for any additional measures related to the use of products from cattle, swine, or goat clones as human food"[3].

The last statement on "any additional measures" is somewhat ambiguous at the first glance. BBC News explained it clearly: "the agency suggested that the results meant it would be unlikely to recommend placing special labels on food from cloned animals." [4]

 

Comments in BBC News: in Have Your Say

 

The US Government refuses to mandate labelling of GM and cloned food. They then threaten economic sanctions against any country blocking imports to protect the profits of their biotech industry.

I want the freedom to choose whether I consume these things or not. Since the products are not labelled the only way I can exercise my choice is to not buy any food that says "made in USA."

I'm not anti-American. I just believe that the risks of releasing GMOs into the environment are unacceptable.

Paul Stimpson, Farnborough, UK

 

Americans can do what they like regarding GM food, cloned meat, and so on - as long as it is in their own country. My objection is that the US forces this weird science on the rest of us under threat of a trade embargo. As a country founded on freedom, the US seemingly grants no freedom to the rest of us.

Paul Robinson, Abingdon, UK

 

Like some other posters, I can't really understand the perceived benefits from cloned animals - increased meat yield perhaps, but given how cheap meat is these days, so what?

I would be worried more about narrowing of the gene pool from widespread cloning. We already see problems from over-breeding in some stock: it cannot be sensible to go further down this route.

Jon Doust

 

I think this is a disgrace to the human race. Why would the FDA even allow this and then state that it may not require a label. I've decided that fish and very little fish will be my choice of meat. I've even decided to grow my own vegetables and fruit and preserve them like my grandmother did 60 years ago. I'm appalled!!!

Megan, Warren, Michigan, USA

 


 

Science-based

In a scientific sketch, an animal clone is a genetic copy of a donor animal, similar to identical twins but born at different times. That is, cloning does not change the gene sequence. This sustains FDA's judgment and belief in human food derived from clone's progeny, but is it enough for issuing an anonymous passport?

Because their DNAs are the same, it's safe as the naturally breeding livestock, really? This logic poses more uncertainties. Today's cell biology can not give definitive answer to any cell-related problem such as aging, cancer, AIDS and so on. It's only at the very earlier stage of full understanding of complex interactions within a mammal's cell, let alone the biological interactions and transformations happened in larger scale, a body.

Moreover, note that the first animal, a sheep, Dolly, was just successfully cloned in 1996; and there already exists very negative evidence on clone reproducing of mice [5]. The period of a five-year study is too short to assess the long-term influence on individual consumer and society.

Therefore, concerning our today's progresses in biology, it's not convincible for scientifically evaluating the final influence of reproductive cloning and eating foods produced from clones' offspring. That's an impossible task now.

 

Roadmap of Clone:  
Species of animals that have been cloned
 *

Species

References

Clone Ref.01

1997 Sheep HRimage


1997 Sheep HRimage

Clone Ref.01-1 

Campbell, K. H. ; McWhir, J. ; Ritchie, W. A. & Wilmut, I. 
Sheep cloned by nuclear transfer from a cultured cell line.
Nature 380 (6569), 64 – 67 (1996).
doi: 10.1038/380064a0 | CrossRef  XLinks :: PubMed | ISI | ChemPort
NPG :: Abs . PDF 
Printed 19960307 

Clone Ref.01-2  

Wilmut, I.; Schnieke, A. E.; McWhir, J.; Kind, A. J. & Campbell, K. H. S.   
Viable offspring derived from fetal and adult mammalian cells.
Nature 385 (6619), 810 – 813 (1997).
doi : 10.1038/385810a0 | CrossRef
NPG :: Abs . PDF 
Printed 19970227 

 Clone Ref.02

 1998 Mouse HRimage


1998 Mouse HRimage

Clone Ref.02-1

Wakayama, T.; Perry, A. C.; Zuccotti, M.; Johnson, K. R. & Yanagimachi, R. 
Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei.
Nature 394 (6691), 369–374 (1998). 
doi : 10.1038/28615 | CrossRef  
XLinks :: PubMed | ISI | ChemPort
NPG :: Abs . FigureTable . Full . PDF 
Printed 19980723 

Clone Ref.02-2

Wakayama, T.; Shinkai Y.; Tamashiro K. L.; Niida H.; Blanchard D. C.; Blanchard R. J.; Ogura A.; Tanemura K.; Tachibana M.; Perry A. C.; Colgan D. F.; Mombaerts P. & Yanagimachi R. 
Cloning of mice to six generations.
Nature 407, 318 – 319 (2000).
doi: 10.1038/35030301 | CrossRef 
XLinks:: PubMed
NPG :: Abs . FigureTable . Full . PDF

Clone Ref.02-3

Teruhiko Wakayama, Ryuzo Yanagimachi
Mouse cloning with nucleus donor cells of different age and type.
Molecular Reproduction and Development 58 (4), 376 – 383 (2001).
doi: 10.1002/1098-2795(20010401)58:4<376::AID-MRD4>3.0.CO;2-L | CrossRef
Wiley-Liss :: Abs . Ref . PDF 
Online 20010223; Printed 20010401 

 Clone Ref.03 

 2002 Cow HRimage


2002 Cow HRimage
Erik J. Forsberg, Nikolai S. Strelchenko, Monica L. Augenstein, Jeffery M. Betthauser, Lynette A. Childs, Kenneth J. Eilertsen, Joellyn M. Enos, Todd M. Forsythe, Paul J. Golueke, Richard W. Koppang, Gail Lange, Tiffany L. Lesmeister, Kelly S. Mallon, Greg D. Mell, Pavla M. Misica, Marvin M. Pace, Martha Pfister-Genskow, Gary R. Voelker, Steven R. Watt & Michael D. Bishop 

Forsberg, E. J.; Strelchenko, N. S.; Augenstein, M. L.; Betthauser, J. M.; Childs, L. A.; Eilertsen, K. J.; Enos, J. M.; Forsythe, T. M.; Golueke, P. J.; Koppang, R. W.; Lange, G.; Lesmeister, T. L.; Mallon, K. S.; Mell, G. D.; Misica, P. M.; Pace, M. M.; Pfister-Genskow, M.; Voelker, G. R.; Watt S. R. & Bishop, M. D.
Production of Cloned Cattle from In Vitro Systems
Biol Reprod 67, 327-333 (2002). [Biology of Reproduction]
Society for the Study of Reproduction, Inc. :: Abs . Full . PDF 
 Clone Ref.04 

 2002 Goat HRimage

2002 Goat
2002 Goat HRimage
Keefer, C. L.; Keyston, R.; Lazaris, A.; Bhatia, B.; Begin, I.; Bilodeau, A. S. ; Zhou, F. J.; Kafidi, N.; Wang, B.;  Baldassarre, H. & Karatzas, C. N.
Production of Cloned Goats after Nuclear Transfer Using Adult Somatic Cells.
Biol. Reprod. 66, 199 – 203 (2002). [Biology of Reproduction]
Society for the Study of Reproduction, Inc. :: Abs . Full . PDF
 Clone Ref.05 

 2003 Mule HRimage

2003 Mule
2003 Mule HRimage
Woods, G. L.; White, K. L.; Vanderwall, D. K.; Li, G. P.; Aston, K. I.; Bunch, T. D.; Meerdo, L. N. & Pate, B. J.
A mule cloned from fetal cells by nuclear transfer.
Science 301 (5636), 1063 (2003).
doi: 10.1126/science.1086743 | CrossRef  
XLinks :: PubMed
AAAS :: AbsTOC . Full . PDF . Supp.Info. 
Science Express online 20030529; Printed 20030822
 Clone Ref.06 

 2003 Horse HRimage

2003 Horse
2003 Horse HRimage
Galli, C.; Lagutina, I.; Crotti, G.; Colleoni, S.; Turini, P.; Ponderato, N.; Duchi, R. & Lazzari, G.
Pregnancy: a cloned horse born to its dam twin.
Nature 424, 635 (2003).
doi :: 10.1038/424635a | CrossRef  
XLinks :: PubMed | ISI
NPG :: Abs . FigureTable . Full . PDF . Supp.Info. 
Printed 20030807 
 Clone Ref.07 

 2002 Rabbit HRimage

2002 Rabbit
2002 Rabbit HRimage
Patrick Chesné, Pierre G. Adenot, Céline Viglietta, Michel Baratte, Laurent Boulanger & Jean-Paul Renard Chesne P, Adenot P. G.; Viglietta C.; Baratte M.; Boulanger L. & Renard J. P.
Cloned rabbits produced by nuclear transfer from adult somatic cells.
Nat. Biotechnol. 20, 366 – 369 (2002).
doi :: 10.1038/nbt0402-366 | CrossRef  
XLinks :: PubMed | ISI
NPG :: Abs . FigureTable . Full . PDF 
Clone Ref.08 

 2002 Cat HRimage

2002 Cat
2002 Cat HRimage
Taeyoung Shin, Duane Kraemer, Jane Pryor, Ling Liu, James Rugila, Lisa Howe, Sandra Buck, Keith Murphy, Leslie Lyons and Mark

Westhusin Shin, T. Y.; Kraemer, D.; Pryor, J.; Liu, L.; Rugila, J.; Howe, L.; Buck, S.; Murphy, K.; Lyons, L. & Westhusin, M.
A cat cloned by nuclear transplantation.
Nature 415 (6874), 859 (2002).
doi :: 10.1038/nature723 | CrossRef  
XLinks :: PubMed | ISI
NPG :: Abs . FigureTable . Full . PDF . Supp.Info.  
Printed 20020221 
 Clone Ref.09  2000 Pig HRimage
2000 Pig
2000 Pig HRimage

Irina A. Polejaeva, Shu-Hung Chen, Todd D. Vaught, Raymond L. Page, June Mullins, Suyapa Ball, Yifan Dai, Jeremy Boone, Shawn Walker, David L. Ayares, Alan Colman and Keith H. S. Campbell.

Polejaeva, I. A.; Chen, S. H.; Vaught, T. D.; Page, R. L.; Mullins, J.; Ball, S.; Dai, Y. F.; Boone, J.; Walker, S.; Ayares, D. L.; Colman, A. & Campbell, K. H. S.  
Cloned pigs produced by nuclear transfer from adult somatic cells.
Nature 407 (6800), 86-90 (2000).
doi :: 10.1038/35024082 | CrossRef 
XLinks :: PubMed | ISI
NPG :: Abs . FigureTable . Full . PDF . Supp.Info. 
Printed 200000907 

 Clone Ref.10

 2005 Dog HRimage

2005 Dog
2005 Dog HRimage

Byeong Chun Lee, Min Kyu Kim, Goo Jang, Hyun Ju Oh, Fibrianto Yuda, Hye Jin Kim, M. Hossein Shamim, Jung Ju Kim, Sung Keun Kang, Gerald Schatten and Woo Suk Hwang 

Lee, B. C.; Kim, M. K.; Jang, G.; Oh, H. J.; Yuda, F.; Kim, H. J.; Shamim, M. H.; Kim, J. J.; Kang, S. K.; Schatten G. & Hwang W. S.
Dogs cloned from adult somatic cells.
Nature 436 (7051), 641 – 641 (2005).
doi :: 10.1038/436641a | CrossRef  
XLinks :: PubMed | ISI
NPG :: Abs . FigureTable . Full . PDF . Supp.Info.   
Printed 20050804 

Snuppy verdict

S1 20050825 Corrigendum.
S2 20060309 Corrigendum.
S3 20060309 Brief Communications Arising.
S4 20060309 Brief Communications Arising.
S5 20061012 Corrigendum

 Clone Ref.11

 2003 Rat HRimage

2003 Rat
2003 Rat HRimage
Qi Zhou, Jean-Paul Renard, Gaëlle Le Friec, Vincent Brochard, Nathalie Beaujean, Yacine Cherifi, Alexandre Fraichard and Jean Cozzi

Zhou, Q.; Renard, J. P.; Friec, G. L.; Brochard, V.; Beaujean, N.; Cherifi, Y.; Fraichard, A. & Cozzi, J.
Generation of Fertile Cloned Rats by Regulating Oocyte Activation
Science 302 (5648), 1179 (2003) .
doi :: 10.1126/science.1088313 | CrossRef
AAAS :: AbsTOC . Full . PDF . Supp.Info. 
Science Express Online 20030925; Printed 20031114
 Clone Ref.12

 2003 Deer HRimage

2003 Deer
2003 Deer HRimage
20031222
CVM Researchers First to Clone White-tailed Deer Link  

 

Dewey, the world's first deer clone was born May 23, 2003
Photo Credits: Courtesy of the College of Veterinary Medicine, Texas A&M University.

© Photo Credits: The authors and their organizations. 

* References' order based on FDA report: A Risk-Based Approach to Evaluate Animal Clones and Their Progeny – DRAFT Chapter II: Technology Overview: Somatic Cell Nuclear Transfer and Other Assisted Reproductive Technologies. >> Link  

 

 

Super-potential without labelling:
Next-generation Weapons of Mass Destruction in the Name of CLONE

 

CLONE MEAT: next WMD?
Credit:
Scidea Art 2007 Source: ScideaNews.com

 

Yes, if regardless of my feeling, and just upon the clone's technique design depicted in nominal science definition—"DNA coping but not altering", I can accept to eat such a food as an individual. However, in the opposite direction of FDA's repeated stress in that lengthy and narrow report —"The main use of clones is to produce breeding stock, not food", I prefer to eat the food derived from the clone itself rather than its offspring, because I don't want to give so much time to the cloned animal for its possibly enhanced probability of gene mutation.

At this point, let's return back to the negative report on cloning from Cornell University in New York, US [5].The scientists found cloned mice embryos had significant development problems. And they also observed unusual patterns of genetic development in the clones. It can not explain clear why the unusual patterns are, but it certainly resulted from the inevitable interference with embryo during cloning, and subsequent unexpected changing or mutation for fit in the cells due to this artificial interference.

We need not hundreds pages of assessment report to claim its safe and great potentials. Before every puzzle has been solved, one negative evidence is just enough for rejection to the widespread application of clone and its products. 

Yes, cloning as well as other advanced bio-techs such as genetic engineering etc. gives great chances for human health. However, if we just care of profit and do not limit their applications in severely controlled scope, the final influence on human race could be fatal.

Yes, clone may mean the better quality of the foods, the more yields thus more profit for US, and at last, for the world. However, mass-productivity within a short time and narrow foods' sources pose much higher risks for our community. And more importantly, in the Name of CLONE, and shielding with no-labelling recommended clearly by FDA's strong safe belief, it's so easy and cost-effective to make new-generation Weapons of Mass Destruction by adding some designed DNA in our foods.

The United States could soon become the first country to allow milk and meat from cloned animals into the food supply. If the above-mentioned WMD is possible, who would be the first country to claim a war with other in the Name of CLONE?

Therefore, the widespread application of clone is too early to hope for a good outcome. FDA's no-labelling is indeed a double-edged sword. This exaggerated belief in science is not only an abuse of authority but also outrageous infringement of human rights.

 

* Lin PU is in the Physics Department of Nanjing University, Nanjing 210093, CHINA.

 

References

 
  
1

FDA: 20061228 FDA Issues Draft Documents on the Safety of Animal Clones.

2FDA: 20061228 A Risk-Based Approach to Evaluate Animal Clones and Their Progeny – DRAFT.
3

FDA: 20061228 Guidance for Industry Use of Edible Products from Animal Clones or their Progeny for Human Food or Animal Feed.

4

BBC News: 20061228 US body backs sale of cloned food.

5

BBC News: 20040630 Scientists renew cloning warnings.

  



Citation

L. PU 

Lin PU. Clone: who wants to back sale of source-anonymous meat? Scidea Sketch 1 (2), ss20070101a1 (2007). 

doi: 10.3128/ss20070101a1 | Scidea :: Abs . Full | CrossRef 
Scidea Sketch :: ISSN: 1992 - 8548 
 

 

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