Blood & bone
Scidea TOS
tos20061004
Small doi: 10.1002/smll.200600177 | Online 20061002 | Abs | Full |
urgently acting with blood and bone
Now maybe we can set a bone once broken and stanch blood as soon as possible. Days ago, Galen D. Stucky's group reported in Small that the modified mesoporous materials of bioactive glasses [SiO2-CaO-P2O5-MO (M=Na, Mg, etc.)] showed faster biological response to simulated body fluids, thus could have a great potential for in vivo bone-forming bioactivity and accelerated blood-clotting. The materials are spherical particles full of bottlelike nanopores. The particles have tuned diameters ranging from 100 nm to 1 μm, and the calculated BET surface area, pore volume, and pore size are on the order of 390 m2/g, 0.70 cm3/g and 7 nm, respectively.
Just after one hour of immersion in simulated body fluids, XRD indicated the deposition of rodlike hydroxyapatite nanocrystalline within the skeleton of the sample with low Si/Ca ratio. The precipitate is calcium-deficient form of Ca10-x(HPO4)x(PO4)6-x(OH)2-x (1.33< x <1.67), however, comparable hydroxyapatite crystallinity was observed on irregularly shaped bioactive glass (stoichiometric, x=0) after about one day. The authors believed that this rapid bioactivity should be attributed to calcium-deficient hydroxyapatite that precipitated during the setting period. As to the sample with high Si/Ca ratio, they proved that the sample can be used as rapid-acting hemostatic agent. Because this material releases CaII ions upon hydration, said the authors, is able to concentrate blood constituents through capillary absorption of fluid-phase media, and is composed of an insoluble inorganic core that could provide an effective support for thrombosis.
All-pervasive interaction
Credit: Scidea Art 2006 Source: ScideaNews.com
* Lin Pu is in the Physics Department of Nanjing University, Nanjing 210093, CHINA.
Citation
L. PU
Lin PU. Urgently acting with blood and bone. Scidea Sketch 1 (1), ss20061100a1 (2007).
♦ doi: 10.3128/ss20061100a1 | Scidea :: Abs . Full | CrossRef
♦ Scidea Sketch :: ISSN: 1992 - 8548